Inter go into a must-win game with Viktoria Plzen in the Czech Republic with Andre Onana, Joaquin Correa and Edin Dzeko starting.
It kicks off at 17.45 UK time (16.45 GMT).
The Nerazzurri started their Champions League campaign with a 2-0 home defeat to Bayern Munich, and this evening the Germans go head-to-head with Barcelona in this very tough group.
Romelu Lukaku is injured and Hakan Calhanoglu not fully fit, while Lautaro Martinez is among those rested after the 1-0 Serie A win over Torino.
Instead, Correa and Dzeko form the partnership upfront, while Onana returns in goal rather than Samir Handanovic.
Francesco Acerbi gets his Inter debut after a transfer deadline day loan move from Lazio.
Viktoria Plzen lost 5-1 to Barcelona in their opening game, and are without injured Jan Kopic and Jan Kliment, while Tomas Chory and Milan Havel start despite carrying knocks.
Viktoria Plzen: Stanek; Havel, Hejda, Pernica, Jemelka; Kalvach, Bucha; Sykora, Vlkanova, Mosquera; Chory
Viktoria Plzen bench: Tvrdon, Jedlicka, Tijani, Pilar, Cermak, Holik, Jirka, Bassey, Ndiaye
Inter: Onana; Skriniar, Acerbi, Bastoni; Dumfries, Barella, Brozovic, Mkhitaryan, Gosens; Correa, Dzeko
Inter bench: Handanovic, Cordaz, Gagliardini, De Vrij, Lautaro Martinez, Bellanova, Asllani, Calhanoglu, Dimarco, D’Ambrosio, Darmian