Napoli are still missing Kvicha Kvaratskhelia, so Giacomo Raspadori steps in with Victor Osimhen, as Empoli seek a fourth consecutive Serie A victory against the Partenopei.
It kicks off at the Stadio Diego Armando Maradona at 17.30 GMT.
You can follow all the build-up and action as it happens from this game, Spezia-Udinese and Cremonese-Milan on the LIVEBLOG.
Luciano Spalletti’s men are six points clear at the top of the table and hoping to make it 10 Serie A wins in a row.
However, Empoli are famously a real bogey team for them, winning their last three top flight meetings, home and away.
Kvaratskhelia and Amir Rrahmani are still not fully fit, so Raspadori completes the trident attack this time with Osimhen and Matteo Politano.
Empoli earned a surprise 1-0 win over Sassuolo at the weekend to put them comfortably mid-table, but Mattia Destro, Koni De Winter and Lorenzo Tonelli are out of action.
Inter-owned Martin Satriano leads the attack with Nedim Bajrami and Tommaso Baldanzi.
Napoli: Meret; Di Lorenzo, Kim Min-jae, Ostigard, Mario Rui; Anguissa, Lobotka, Ndombele; Politano, Osimhen, Raspadori
Empoli: Vicario; Stojanovic, Ismajli, Luperto, Parisi; Haas, Marin, Bandinelli; Baldanzi; Bajrami; Satriano